AT AGE 45, my LDL (“bad”) cholesterol had spiraled out of control. I was doing everything “right”—for most of my adult life, I’ve maintained mostly 12 to 13 percent body fat, I’ve eaten a plant- and protein-rich whole foods diet, and I’ve consistently exercised. Yet my cholesterol climbed to 271 mg/dL—more than twice the “optimal” limit. It didn’t make sense.
No one could explain why my LDL cholesterol was so high. The most logical explanation—a condition called familial hypercholesterolemia (FH)—wasn’t comforting: It was genetics, and research shows that people with very high LDL and FH have a 22 times greater risk of developing coronary artery disease.
FH is treatable thanks to statin therapy. But while I’m not anti-statin, I was concerned that by starting one, I’d lower my LDL but perhaps wouldn’t be addressing a deeper health issue that was causing the elevated lipids. I wasn’t ready to risk that until I’d exhausted every other option. I wanted to make one more big push to lower my dangerously high cholesterol through nutrition, exercise, and lifestyle optimization. Trouble is, over the past few years, I’d only had modest success.
As the CEO of Precision Nutrition—a global leader in health, nutrition, and behavior-change coaching—I’m not lacking know-how or resources for improving my health and fitness. But I was now in “ruthless optimization” mode, which meant it was time to get molecular.
ENTER ANDY GALPIN, Ph.D., C.S.C.S. *D, a rock-star kinesiologist at California State University, Fullerton. Among his clients are some of the world’s most elite athletes, including NBA All-Stars, Olympic gold medalists, and MMA champions. I worked with Galpin because he’s also a cofounder of Rapid Health Optimization(RHO), where he and partner Dan Garner specialize in designing highly individualized plans—known as “biomolecular blueprints”—for high-performing people who want to unlock their true physiological potential. They’re the most innovative health-optimization experts on the planet.
What they do is seriously cutting-edge stuff that looks for micronutrient deficiencies, blood-marker abnormalities, hidden stressors, and optimization opportunities, and I hoped it would finally offer the cholesterol breakthrough I’d been searching for.
I set out to lower my LDL cholesterol, not my body fat. But the small shifts I made in eating, sleeping, working out, and managing stress ended up taking me from 16 percent body fat to 10 percent.
Optimization requires a lot of jabbing, spitting, pooping, and peeing. But it was necessary so Galpin and Garner could analyze more than 1,000 biomarkers related to my hormone health, antioxidant levels, gut health, brain chemistry, inflammation, metabolism, and vitamin and mineral status. They also collected deep insights through psychological evaluations, rigorous fitness testing, and a clinical-grade at-home sleep study. Then they created a state-of-the-art protocol customized to optimize my health from every angle you can imagine.
Full transparency: Many of these recommendations, including certain supplements, were based on my specific test results, so they don’t apply to everyone. For example, blood tests showed that my body carried a “high chemical load,” so I was advised to eliminate foods, drinks, and personal hygiene products stored in plastic containers. (Metal, glass, and cardboard were acceptable.) We also discovered that I had H. pylori, a potentially problematic bacterial infection in my gut, which was cleared up with an antibiotic and further treated with a broad-spectrum probiotic.
Those “hidden stressors,” as Galpin calls them, were important to address for my overall health and could have been contributing to my cholesterol complications. But there were other, more universal factors that were critical. Some of them might not seem groundbreaking. Everyone knows that eating right and moving more help your cholesterol. The question was whether getting to the bottom of exactly what was off and being precise about how to change it would give me a plan that really worked. Through RHO, I also tracked everything and had experts review it, which helped me see the effectiveness of my actions. It also allowed us to shift things as we went along to focus on the biggest opportunities.
WHEN YOU HEAR “optimization,” it’s natural to think “perfection.” But that’s not the case. “We know people are human,” says Galpin. “We’re just trying to stack the deck with as many things in the right direction as possible, as often as possible.”
And therein lies the secret: It wasn’t one never-before-seen “hack” that drove my life-changing results. Instead, it was learning how to consistently integrate the following five proven principles into my everyday life. Each is helpful on its own, but together, as I started to see over the next two years, their transformative power is exponentially greater. It’s one thing to know the principles to follow and another to put them into practice; I was fortunate to have a breakthrough with each that helped me execute them. Every one of the following strategies made me feel better, stronger, and leaner. Would my blood work reveal that they could trump a troubling family history?
Principle #1: Optimize Your Cardiovascular Fitness
I’ve always prided myself on maintaining peak physical fitness. But tests showed my VO2 max, a measure of cardiovascular fitness, was “insufficient.” This wasn’t because I was out of shape. It was because Galpin sees this as the biggest health optimization opportunity—a measure that nearly everyone can and should push higher. “VO2 max is one of, if not the most, significant predictors of how long and how well you’re going to live,” he says. “It consistently outpredicts smoking, diabetes, and coronary artery disease.” Whether through exercising more, losing body fat, or boosting VO2 max itself, the RHO team has seen cholesterol drop as a result of optimizing cardiovascular fitness.
No need to overcomplicate it, though. “Find an activity you like that challenges your cardiovascular system, and consistently strive to improve your performance,” says Galpin. I took up boxing, Muay Thai, and Krav Maga, which provided high-intensity interval-like training that moved my VO2 max over the 90th percentile for my age.
Breakthrough Strategy: Find Your People
Soon after I started boxing, it became the highlight of my day. Not just because I like hitting stuff, but also due to the human connection the activity fosters. Like a kid excited for recess, I genuinely look forward to bonding with my new friends over tough training sessions, learning new skills, and our shared passion.
Finding the right community, as I did with this boxing group in Nosara, Costa Rica, made me never want to miss a workout.
Principle #2: Focus on Protein and Fiber
“Eat more protein and fiber” is probably the least inspiring advice ever. Everyone’s heard it—but most people don’t actually do it. What might happen if you did, though? Great things, says Galpin.
“If you consistently achieve the daily targets we set for protein and fiber, you’re likely to be shocked at what happens to your junk food cravings, meal satisfaction, and overall calorie intake,” he explains. “The sheer volume of food will fill you up, displace higher-calorie processed foods, and give you an infusion of healthful nutrients.”
So what are these daily targets?
Protein: 1 gram per pound of bodyweight, though Galpin says that hitting 80 percent of that number is good enough. (American men generally consume about half that amount.)
Fiber: 38 grams, which is the daily amount recommended for men by the Institute of Medicine and about 20 grams more than the average American guy consumes per day.
When I prioritized my protein target and gradually upped my fiber intake from 24 grams to more than 38 grams a day—by eating more fiber-rich produce, beans, and steel-cut oats—not only did my LDL cholesterol improve, but it had never felt easier to lose fat.
Breakthrough Strategy: Go Small and Easy
Don’t try to double how much protein and fiber you get overnight. Instead, start by adding just 10 to 20 grams of protein and 5 to 10 grams of fiber to your daily intake. Once you’re having that much consistently for two weeks, repeat the process until you reach your targets. An easy way to do that: Anytime you have the chance, make a choice that’s slightly better than you might have otherwise. Having a burger? Put a tomato slice on it. Already do that? Have two slices. When improving nutrition, we’ve all been taught to subtract; start figuring out how to add instead.
Testing and tracking all of my moves helped us keep close tabs on which ones were working and which had less impact.
Principle #3: Track What You Want to Improve
For two years, I’ve tracked just about every health, nutrition, and fitness metric imaginable. I’ve recorded my daily calories, protein, carbs, and fat with an app called Cronometer; workout intensity with a Polar heart-rate sensor; activity levels and sleep patterns with an Oura ring; blood sugar with a NutriSense continuous glucose monitor; and bodyweight, fat percentage, and circumference with FitIndex. The team at Absolute Rest provided tools for assessing sleep quality, and InsideTrackerhelped me monitor my blood biomarkers.
Here’s what I learned: Tracking is invaluable for showing you what’s actually happening—versus what you think is happening. And that awareness? It can be a game changer.
Breakthrough Strategy: Pick Your Spots
You don’t need to track everything at once or even track long-term. But if you aren’t getting the results you want, use tracking for a couple of weeks to fact-check your assumptions. Not losing fat? Track your food intake and activity levels. Have constant cravings? Track your sleep length or quality.
Pull quote: Tracking is invaluable for showing you what’s actually happening—versus what you think is happening.
Principle #4: Prioritize Sleep Like Your Results Depend on It
I thought I was sleeping well, but according to my test results, I had a borderline sleep disorder—with several waking events per night. That was likely causing me “invisible” problems. “Poor sleep quality can have a negative impact on your mood, physical performance, cognitive capacity, stress levels, appetite, immune function, sex drive—you name it,” says Galpin. “It makes everything harder.” Some evidence suggests that sleep disturbances can adversely affect cholesterol. Plus, good sleep sets the stage for making other changes that contribute to healthy cholesterol.
Galpin says the first order of business is to set a regular bedtime—one that allows for a consistent minimum of seven hours of sleep. “Consistency of your sleep schedule is even more important than getting eight hours,” he says. “It resets your circadian rhythm and hormonal responses, which leads to fewer awakenings and makes the sleep you do get far more restful.”
Breakthrough Strategy: Build your awareness
If you have an Oura ring, Apple Watch, Whoop, or other way to measure your sleep duration and consistency, simply keep track of a behavior that affects sleep—such as alcohol intake, device use before bed, caffeine intake, or the time you go to bed—and see what your sleep data tells you the next morning. It’s easy to do, but the results can be enlightening.
For example, before tracking, I would’ve told you that one glass of wine had zero effect on my shut-eye. But my sleep data tells a different story. When I have a drink, my resting heart rate is higher, my heart rate variability (a measure of recovery and stress resilience) is lower, and I get less restorative deep sleep. While I still occasionally have wine, I now fully understand what the trade-off for that drink is. Is it really worth it? More often than not, my answer is no.
Optimization involved collecting data: blood tests every few months (left), VO2 max testing (center), and Absolute Rest sleep testing (right).
Principle #5: Stress Management Is the X Factor
Without consistently practicing stress management, I’m confident my LDL cholesterol would still be through the roof. Research shows that stress increases appetite, negatively impacts sleep, saps motivation to exercise, and impairs decision-making ability.
And my stress level? It might’ve trumped my LDL. During the past few years, I’ve had to navigate my company through the economic impact of Covid, I’ve struggled with personal relationships, I’ve lost some friends, and, tragically, my 39-year-old sister died in a car accident.
But the reality is this: We all have a lot of stress. And if you don’t work to manage it, staying the course with your health, nutrition, and fitness can feel impossible. When people ask me how I’ve been so consistent, I tell them stress management is the number-one reason.
Breakthrough Strategy: Think on a Continuum
As you know—and I can assure you—life will never go perfectly. You’ll get sick. You’ll have a work disaster. You’ll forget your lunch. For many people, these situations trigger a perfectionist, “all or nothing” mindset, often resulting in nothing. (“I can’t work out for 45 minutes, so I’ll skip the whole thing.”) That leads to self-criticism—which increases mental distress. Don’t succumb to the perfectionist’s dilemma. Instead, always choose to do “something,” no matter how small. With practice, you become more adaptable and resilient, both of which reduce feelings of stress.
WITH ALL THESE strategies put together, I not only cut my LDL cholesterol in half (yes, it’s 135 now), but I’m now the leanest, fittest, and healthiest I’ve ever been. What I learned along the way may have added years, if not decades, to my life. I’m not suggesting that you have to go through all the tests and assessments that I did. But what I discovered might help other guys do the same. Ten percent body fat was never my goal, and I wasn’t trying to get shredded. But as side effects go, they’re pretty hard to beat. The icing on the cake: At my current chronological age, 47, my estimated biological age based on my blood tests is 37.
Two years after my experiment started, I was healthier and fitter than ever.
MOST COMEBACK STORIES wrap up here. But mine was just beginning. That’s because I injured my Achilles tendon just one month before my first appointment with RHO. It would’ve been totally acceptable to say, “I’m going to hold off until after my recovery,” but I forged ahead anyway.
“Holy cow. That’s crazy.” The text was from Sagar Desai, M.D., one of the world’s foremost orthopedic surgeons. He was reacting to the video I’d just sent him: me, kite-foiling on Lake Ontario 99 days after he’d surgically repaired my ruptured Achilles. (According to Dr. Desai, it typically takes his patients five to six months to return to sports-related activities.)
It wasn’t easy: During my Aaron Rodgers–like recovery, I gained 12 pounds in eight weeks, thanks to lower activity levels. As a result, my LDL increased by 110 points. So, even though I was making extremely fast progress with my Achilles, it felt like I was going backward with my overall health. But if I’d waited until I was fully recovered? Those numbers would’ve likely been much worse. Plus, maybe I wouldn’t have healed so fast. And perhaps I’d even have become demoralized and given up altogether.
There was an important lesson here: Progress isn’t always visible. One tiny action, no matter how imperceptible, can put you in a better place today than you were in yesterday. That’s how you gain momentum. And as your momentum builds, something magical happens: It becomes easier to make progress—and way harder to stop.
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